Imipenem monohydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

半合成硫霉素对革兰氏阴性和革兰氏阳性需氧和厌氧细菌具有广谱抗菌活性。

Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.

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Imipenem monohydrate (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent.Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single). Animal Model:Neutropenic mouse model of biofilm lung infection Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg Administration:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single Result:Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.

N-Formimidoyl Thienamycin

GPCR/G Protein

Antibacterial

PBPs| β-Lactamase

Infection

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74431-23-5

317.36

C12H19N3O5S

>98% (HPLC)

Soluble in Water

C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.O

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(-20℃)

With Ice Pack

≥ 2 years